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Transplantation of cryopreserved and fresh rat islets and canine pancreatic fragments: comparison of cryopreservation protocols.

Authors
  • Rajotte, R V
  • Warnock, G L
  • Bruch, L C
  • Procyshyn, A W
Type
Published Article
Journal
Cryobiology
Publication Date
Apr 01, 1983
Volume
20
Issue
2
Pages
169–184
Identifiers
PMID: 6406151
Source
Medline
License
Unknown

Abstract

(1) The freezing protocol we have devised for rat islets results in normal clinical indices and almost normal glucose tolerance in diabetic recipients of the same inbred strain. (2) Cryopreservation of canine islet-containing pancreatic tissue required a higher temperature than rat islets during exposure to the protective agent. (3) Because of the similar compactness of the pancreas in man and dog, we consider this canine model useful for formulating optimal cryopreservation techniques for the human pancreas. (4) Cryopreservation may partially purify islet-containing tissue of its exocrine content.

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