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Transmembrane topology of the glutamate receptors. A tale of novel twists and turns.

Authors
  • Hughes, T E
Type
Published Article
Journal
Journal of molecular neuroscience : MN
Publication Date
Jan 01, 1994
Volume
5
Issue
4
Pages
211–217
Identifiers
PMID: 7577364
Source
Medline
License
Unknown

Abstract

The glutamate receptor subunits were first thought to cross the cell membrane four times in a manner analogous to the neuronal nicotinic acetylcholine, GABAA, and glycine receptors. This model led the field for nearly five years, although it was frequently in conflict with the data. Recently, comparisons with bacterial proteins, epitope tagging experiments, and the construction of chimeras has produced a new model of glutamate receptor topology that is novel and quite unlike any of the other receptors.

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