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Transmembrane redox signaling activates NF-kappaB in macrophages.

Authors
  • Kaul, N
  • Choi, J
  • Forman, H J
Type
Published Article
Journal
Free Radical Biology and Medicine
Publisher
Elsevier
Publication Date
Jan 01, 1998
Volume
24
Issue
1
Pages
202–207
Identifiers
PMID: 9436632
Source
Medline
License
Unknown

Abstract

In macrophages, NF-kappaB can be activated by H2O2 generated by the respiratory burst or added exogenously. The mechanism of H2O2 signaling may involve changes in the cellular redox state or a redox reaction at the plasma membrane; however, the site of H2O2 action cannot be readily ascertained because of its membrane permeability. Ferricyanide, a nonpermeable redox active anion, activated NF-kappaB in the macrophage cell line, J774A.1. In contrast with exogenous H2O2, activation by ferricyanide did not correlate with net oxidation of NAD(P)H or glutathione, suggesting that a transplasma membrane redox reaction itself was the first signaling process in NF-kappaB activation.

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