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Translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in thioacetamide-induced liver tumours in rats.

Authors
  • Cascales, C
  • Boscá, L
  • Martín-Sanz, P
  • Brindley, D N
  • Cascales, M
Type
Published Article
Journal
Toxicology Letters
Publisher
Elsevier
Publication Date
Apr 01, 1989
Volume
47
Issue
1
Pages
9–16
Identifiers
PMID: 2540549
Source
Medline
License
Unknown

Abstract

The translocation of phosphatidate phosphohydrolase induced by oleate was higher (two-fold) in liver homogenates obtained from long-term thioacetamide-treated rats than from control rats. These differences between thioacetamide-treated and control livers were noticeably higher (four-fold) in the presence of physiological concentrations of salt (0.15 M KCl). In homogenates from control rats, there was a lack of response when physiological concentrations of the salt were present. The enhanced response to translocate phosphatidate phosphohydrolase activity in liver homogenates from thioacetamide-treated rats was due to an increased binding ability of microsomal membranes.

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