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Translational coupling during expression of the tryptophan operon of Escherichia coli.

Authors
  • Oppenheim, D S
  • Yanofsky, C
Type
Published Article
Journal
Genetics
Publication Date
Aug 01, 1980
Volume
95
Issue
4
Pages
785–795
Identifiers
PMID: 6162715
Source
Medline
License
Unknown

Abstract

E. coli trpE polar mutations are 10 time more polar on trpD gene expression than on downstream (trpC, B, or A) gene expression. This effects was shown to be the result of "translational coupling," in which efficient translation of trpE-trpD intercistronic punctuation region consists of overlapping stop and start codons, and the trpE and trpD gene products form a functional complex in the cell. In light observations and characteristics, several models for the mechanism of translational coupling are considered.

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