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Translational coupling during expression of the tryptophan operon of Escherichia coli.

Authors
Type
Published Article
Journal
Genetics
0016-6731
Publisher
The Genetics Society of America
Publication Date
Volume
95
Issue
4
Pages
785–795
Identifiers
PMID: 6162715
Source
Medline

Abstract

E. coli trpE polar mutations are 10 time more polar on trpD gene expression than on downstream (trpC, B, or A) gene expression. This effects was shown to be the result of "translational coupling," in which efficient translation of trpE-trpD intercistronic punctuation region consists of overlapping stop and start codons, and the trpE and trpD gene products form a functional complex in the cell. In light observations and characteristics, several models for the mechanism of translational coupling are considered.

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