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Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid.

Authors
  • Abrahamsson, K1
  • Mellander, M
  • Eriksson, B O
  • Holme, E
  • Jodal, U
  • Jönsson, A
  • Lindstedt, S
  • 1 Department of Paediatrics, Gothenburg University, Sweden. , (Sweden)
Type
Published Article
Journal
British heart journal
Publication Date
Dec 01, 1995
Volume
74
Issue
6
Pages
656–659
Identifiers
PMID: 8541173
Source
Medline
Language
English
License
Unknown

Abstract

To study the effect of induced carnitine depletion on myocardial structure and function. 7 healthy adult volunteers given 1200 mg pivmecillinam per day for 7-8 weeks were studied by echocardiography before and after 7-8 weeks of treatment and a 15 months follow up after the treatment period. Teaching hospital. Carnitine concentration in serum, urine, and muscle and echocardiographic measurements. After 7-8 weeks of treatment the median free serum carnitine concentration was reduced to 7% and the median total muscle carnitine concentration to 46% of the pretreatment levels. The median diastolic interventricular septum thickness decreased by 14% (mean 26%, P = 0.028) and the median left ventricular mass by 10% (mean 20%, P = 0.018). Fifteen months later these dimensions had increased but not completely returned to pretreatment values. Extended treatment with pivalic acid containing antibiotics causes carnitine depletion which may lead to changes in cardiac structure.

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