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A transient proteasome activation is needed for acetic acid-induced programmed cell death to occur in Saccharomyces cerevisiae.

Authors
  • Valenti, Daniela
  • Vacca, Rosa Anna
  • Guaragnella, Nicoletta
  • Passarella, Salvatore
  • Marra, Ersilia
  • Giannattasio, Sergio
Type
Published Article
Journal
FEMS yeast research
Publication Date
May 01, 2008
Volume
8
Issue
3
Pages
400–404
Identifiers
DOI: 10.1111/j.1567-1364.2008.00348.x
PMID: 18218016
Source
Medline
License
Unknown

Abstract

To gain further insight into the mechanism by which yeast programmed cell death (PCD) occurs, we investigated whether and how proteasome activity changes in Saccharomyces cerevisiae cells undergoing PCD as a result of treatment with acetic acid (AA-PCD). We show that proteasome activation starts 60 min after AA-PCD induction, with a maximum at 90 min, and decreases at 150 min. Moreover, cell survival measurements carried out in the absence or presence of MG132, which inhibits proteasome function, show that the inhibition of proteasome activity partially prevents AA-PCD, thus indicating that a transient proteasome activation is needed for AA-PCD to occur.

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