Transient global amnesia (TGA) is a neurological disorder characterized by sudden onset of anterograde amnesia with or without retrograde amnesia, lasting less than 24 hours, without other clinical neurological dysfunction. TGA with short duration and benign prognosis is usually neglected in clinical practice. Transient total amnesia after radiofrequency ablation is rare and its etiology is unknown. We report a case of 27-year-old man who experienced TGA after radiofrequency catheter ablation of supraventricular tachycardia. The patient had no other cognitive and motor impairment except for memory impairment. The symptom lasted for about six hours and relieved without recurrence. Nervous system examination showed that 12 pairs of cranial nerves were normal, the muscle strength and muscle tone of the limbs were normal, physiological reflexes existed, and no pathological reflexes were elicited. Tests were performed immediately and normally including blood routine examination, liver and kidney function, electrolyte, blood glucose, thyroid function, blood coagulation function, D-dimer, myocardial injury markers, blood gas analysis and other hematological. There is no abnormality in electrocardiogram (ECG), chest X-ray, cervical vascular ultrasound, and cardiac color Doppler ultrasound examination. Head magnetic resonance examination magnetic resonance imaging (MRI) showed dots in right frontal lobe and bilateral ventricles in T2-weighted images. There was no cerebral infarction and cerebral hemorrhage. The patient received low flow oxygen inhalation and aspirin 300mg orally. The outcome of patient with TGA is benign. There are still many unsolved mysteries worthy of long-term follow-up.