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Transgenic engineering of male-specific muscular hypertrophy.

Authors
  • Pirottin, Dimitri
  • Grobet, Luc
  • Adamantidis, Antoine
  • Farnir, Frédéric
  • Herens, Christian
  • Schrøder, Henrik Daa
  • Georges, Michel
Type
Published Article
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publication Date
May 03, 2005
Volume
102
Issue
18
Pages
6413–6418
Identifiers
PMID: 15851664
Source
Medline
License
Unknown

Abstract

Using a two-step procedure involving insertional gene targeting and recombinase-mediated cassette exchange in ES cells, we have produced two lines of transgenic mice expressing a dominant-negative latency-associated myostatin propeptide under control of the myosin light chain 1F promoter and 1/3 enhancer from the TSPY locus on the Y chromosome. Males of the corresponding lines are characterized by a 5-20% increase in skeletal muscle mass. This experiment demonstrates the feasibility of a more efficient cattle production system combining superior beef production abilities for bulls and dairy abilities for cows.

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