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Transgenic engineering of male-specific muscular hypertrophy.

Authors
  • Pirottin, Dimitri
  • Grobet, Luc
  • Adamantidis, Antoine
  • Farnir, Frédéric
  • Herens, Christian
  • Daa Schroder, Henrik
  • Georges, Michel
Publication Date
Jan 01, 2005
Source
ORBi
Keywords
Language
English
License
Unknown
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Abstract

Using a two-step procedure involving insertional gene targeting and recombinase-mediated cassette exchange in ES cells, we have produced two lines of transgenic mice expressing a dominant-negative latency-associated myostatin propeptide under control of the myosin light chain 1F promoter and 1/3 enhancer from the TSPY locus on the Y chromosome. Males of the corresponding lines are characterized by a 5-20% increase in skeletal muscle mass. This experiment demonstrates the feasibility of a more efficient cattle production system combining superior beef production abilities for bulls and dairy abilities for cows.

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