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Transfusion practice blind spot in para-Bombay: A case report.

Authors
  • Abdullah, Mohd Redzuan1
  • Faizli, Afif Alam1
  • Noordin, Siti Salmah2
  • Lee, Chin Jian3
  • Ahmad, Nor Hafizah3
  • 1 Regenerative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia (USM), Bertam, 13200, Kepala Batas, Pulau Pinang, Malaysia. , (Malaysia)
  • 2 Regenerative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia (USM), Bertam, 13200, Kepala Batas, Pulau Pinang, Malaysia. Electronic address: [email protected] , (Malaysia)
  • 3 Section of Immunohematology, National Blood Centre, Jalan Tun Razak, Titiwangsa, 50400, Kuala Lumpur, Malaysia. , (Malaysia)
Type
Published Article
Journal
Transfusion and Apheresis Science
Publisher
Elsevier
Publication Date
Feb 03, 2021
Pages
103076–103076
Identifiers
DOI: 10.1016/j.transci.2021.103076
PMID: 33574008
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

H-deficient phenotype individuals with absent or weak anti-H activity may remain undetected on standard routine blood grouping. We report a case of a 59-year-old-man presented with symptomatic anaemia secondary to upper gastrointestinal bleed with haemoglobin level of 68 g/L who required two units of packed red blood cells. He was previously grouped as O Rh D positive and had a history of uneventful multiple blood transfusions. His latest pre-transfusion investigations showed ABO discrepancy between forward and reverse blood grouping, pan-agglutination in both antibody screening and identification with negative direct Coombs test and autocontrol. Further testing including anti-H lectin test and saliva secretor study confirmed that the patient blood group was para-Bombay B RhD positive. This case highlights that the para-Bombay phenotype can be mistakenly labelled as "O" if further investigations are not performed. Copyright © 2021 Elsevier Ltd. All rights reserved.

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