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Transfusion-acquired Hemoglobinopathies: A Report of Two Cases.

Authors
Type
Published Article
Journal
Journal of laboratory physicians
Publication Date
Volume
7
Issue
2
Pages
128–130
Identifiers
DOI: 10.4103/0974-2727.163128
PMID: 26417166
Source
Medline
Keywords
  • High-Performance Liquid Chromatography
  • Posttransfusion Peak
  • Transfusion-Acquired Hemoglobinopathy

Abstract

Transfusion-acquired hemoglobinopathy occurs when a carrier of hemoglobinopathy with no significant abnormalities donates blood, and the blood is transfused to a recipient. This process can lead to spurious results in the recipient without any clinical abnormality or infrequently can result in disastrous situations. The incidental finding of such posttransfusion related abnormal peaks in hemoglobin high-performance liquid chromatography (Hb HPLC) may cause diagnostic dilemmas and result in unnecessary laboratory testing. Here, we report two such cases of transfusion-acquired hemoglobinopathies, which were subsequently resolved by the abnormally low percentage of the Hb variants, transient nature of the peaks, and parental Hb HPLC.

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