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Transformation of blood monocytes to multinucleated giant cells in vitro: are there any differences between malignant and nonmalignant states?

Authors
  • Munzarová, M1
  • Zemanová, D
  • 1 Department of Immunology and Tissue Cultures, Masaryk Memorial Cancer Institute, Brno.
Type
Published Article
Journal
Physiological research
Publication Date
1992
Volume
41
Issue
3
Pages
221–226
Identifiers
PMID: 1286087
Source
Medline
License
Unknown

Abstract

Blood monocytes (BMs) from 139 subjects (70 malignant melanoma patients, 31 breast cancer patients, 38 healthy controls) were cultured for at least 7 days. The formation of multinucleated giant cells (MGCs), which was checked during the whole time of culture, was observed in all cases. By the seventh day MGCs represented 25-50% and during the second and third month more than 90% of all cells. Lymphokines and/or concanavalin A stimulation (16-34 cases respectively) of BMs was performed as well. This stimulation greatly accelerated MGC formation. There were no differences either in spontaneous or in stimulated fusion between the different groups compared.

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