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Transfer of plasmid and chromosomal glycopeptide resistance determinants occurs more readily in the digestive tract of mice than in vitro and exconjugants can persist stably in vivo in the absence of glycopeptide selection.

Authors
  • Dahl, Kristin Hegstad
  • Mater, Denis D G
  • Flores, María José
  • Johnsen, Pål Jarle
  • Midtvedt, Tore
  • Corthier, Gerard
  • Sundsfjord, Arnfinn
Type
Published Article
Journal
The Journal of antimicrobial chemotherapy
Publication Date
Mar 01, 2007
Volume
59
Issue
3
Pages
478–486
Identifiers
PMID: 17283034
Source
Medline
License
Unknown

Abstract

The overall results support the notion that the in vitro model underestimates the transfer potential. Rapid transfer of vanA plasmids from poultry- and pig-derived strains to human faecal E. faecium shows that even transiently colonizing strains may provide a significant reservoir for transfer of resistance genes to the permanent commensal flora. Newly acquired resistance genes may be stabilized and persist in new populations in the absence of antibiotic selection.

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