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Transduction of rat and human adipose-tissue derived mesenchymal stromal cells by adeno-associated viral vector serotype DJ

Authors
  • Zubkova, Ekaterina S.1
  • Beloglazova, Irina B.1
  • Ratner, Elizaveta I.1
  • Dyikanov, Daniyar T.2
  • Dergilev, Konstantin V.1
  • Menshikov, Mikhail Yu.1
  • Parfyonova, Yelena V.1, 2
  • 1 National Medical Research Center of Cardiology, Moscow 121552 , (Russia)
  • 2 Lomonosov Moscow State University, Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Moscow 119991 , (Russia)
Type
Published Article
Journal
Biology Open
Publisher
The Company of Biologists
Publication Date
Sep 08, 2021
Volume
10
Issue
9
Identifiers
DOI: 10.1242/bio.058461
PMID: 34494647
PMCID: PMC8443863
Source
PubMed Central
Keywords
Disciplines
  • Research Article
License
Unknown

Abstract

Summary: Adeno-associated viral vectors are widely used for gene delivery but their impact on the different cell types varies greatly and is not well understood. We describe effects of two most popular AAV serotypes on mesenchymal stromal cells of rat and human origin.

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