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Transdermal selegiline: targeted effects on monoamine oxidases in the brain.

Authors
  • Wecker, Lynn
  • James, Stephanie
  • Copeland, Natalie
  • Pacheco, Mary A
Type
Published Article
Journal
Biological Psychiatry
Publisher
Elsevier
Publication Date
Nov 15, 2003
Volume
54
Issue
10
Pages
1099–1104
Identifiers
PMID: 14625153
Source
Medline
License
Unknown

Abstract

Results suggest that transdermal selegiline preferentially inhibits MAO-A in brain relative to the gastrointestinal system. As a consequence, transdermal selegiline should be devoid of the potential to cause a hypertensive reaction after the ingestion of tyramine-containing compounds.

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