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[Transdermal salicylate absorption following epidermal application of an analgesic / antiphlogistic ointment and gel formulation (author's transl)].

Authors
  • Hüther, K J
  • Hiereth, H
  • Messer, W
Type
Published Article
Journal
Arzneimittel-Forschung
Publication Date
Jan 01, 1982
Volume
32
Issue
1
Pages
69–72
Identifiers
PMID: 7199343
Source
Medline
License
Unknown

Abstract

Following epidermal application of 5 g Dolo-Arthrosenex ointment for gel, respectively, containing 625 mg ethyleneglycol salicylate (corresponding to 473.9 mg salicylic acid) upon a skin area of 100 cm2 of 12 normal volunteers transdermal absorption of salicylate was measured over a period of 48 h after application by means of renal salicylate excretion. A high-pressure liquid chromatography method was employed for the quantitative estimation of urinary levels of salicylic acid and salicyluric acid. Afer application of the ointment in the mean 26.7% of the applied salicylate dose is resorbed within 24 h and excreted within 48 h, respectively. From the gel in the mean 48.0% of the applied salicylate dose is absorbed within 24 h and excreted within 48 h, respectively.

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