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Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription.

Authors
  • Gerasimova, N S1
  • Pestov, N A2
  • Kulaeva, O I1, 3
  • Clark, D J4
  • Studitsky, V M1, 2, 3
  • 1 a Biology Faculty, Lomonosov Moscow State University , Moscow , Russia.
  • 2 b Department of Pharmacology , Rutgers-Robert Wood Johnson Medical School , Piscataway , NJ , USA.
  • 3 c Cancer Epigenetics Program, Fox Chase Cancer Center , Philadelphia , PA , USA.
  • 4 d Division of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health , Bethesda , MD , USA.
Type
Published Article
Journal
Transcription
Publication Date
May 26, 2016
Volume
7
Issue
3
Pages
91–95
Identifiers
DOI: 10.1080/21541264.2016.1182240
PMID: 27115204
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

RNA polymerase II (Pol II) transcription through chromatin is accompanied by formation of small intranucleosomal DNA loops. Pol II captured within a small loop drives accumulation of DNA supercoiling, facilitating further transcription. DNA breaks relieve supercoiling and induce Pol II arrest, allowing detection of DNA damage hidden in chromatin structure.

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