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Transcriptional profile of Haemophilus influenzae: effects of iron and heme.

Authors
Type
Published Article
Journal
Journal of bacteriology
Publication Date
Volume
188
Issue
15
Pages
5640–5645
Identifiers
PMID: 16855256
Source
Medline
License
Unknown

Abstract

Haemophilus influenzae requires either heme or a porphyrin and iron source for growth. Microarray studies of H. influenzae strain Rd KW20 identified 162 iron/heme-regulated genes, representing approximately 10% of the genome, with > or =1.5-fold changes in transcription in response to iron/heme availability in vitro. Eighty genes were preferentially expressed under iron/heme restriction; 82 genes were preferentially expressed under iron/heme-replete conditions.

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