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Transcriptional Landscape of PARs in Epithelial Malignancies

Authors
  • Nag, Jeetendra Kumar
  • Bar-Shavit, Rachel
Publication Date
Nov 02, 2018
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

ER complex to estrogen response elements (ERE) are shown. In addition, evidence that TEA domain 4 (TEAD4) motifs are present within the hPar2 promoter is presented since the YAP oncogene, which plays a central part in tumor etiology, acts via the TEAD4 transcription factor. As of now, no information is available on regulation of the hPar3 promoter. With regard to hPar4, only data showing CpG methylation promoter regulation is available. Characterization of the PAR transcriptional landscape may identify powerful targets for cancer therapies.

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