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Transcriptional and Functional Analysis of CD1c + Human Dendritic Cells Identifies a CD163 + Subset Priming CD8 +CD103 + T Cells

Authors
  • Bourdely, Pierre1, 2
  • Anselmi, Giorgio1, 2
  • Vaivode, Kristine1, 2
  • Ramos, Rodrigo Nalio3
  • Missolo-Koussou, Yoann3
  • Hidalgo, Sofia3, 4
  • Tosselo, Jimena3
  • Nuñez, Nicolas3
  • Richer, Wilfrid3
  • Vincent-Salomon, Anne5
  • Saxena, Alka6
  • Wood, Kristie6
  • Lladser, Alvaro4, 7
  • Piaggio, Eliane3
  • Helft, Julie3
  • Guermonprez, Pierre1, 2, 8
  • 1 & Microbial Sciences, King’s College London, London, UK
  • 2 Cancer Research UK King’s Health Partner Cancer Centre, King’s College London, London, UK
  • 3 PSL Research University, Institut Curie Research Center, Translational Immunotherapy Team, INSERM U932, Paris, France
  • 4 Laboratory of Immuno-oncology, Fundación Ciencia & Vida, Santiago, Chile
  • 5 PSL Research University, Institut Curie, Department of Biopathology, Paris, France
  • 6 National Institute of Health Research Biomedical Research Centre at Guy’s and St Thomas’ Hospital and King’s College London, London, UK
  • 7 Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile
  • 8 Université de Paris, Centre for Inflammation Research, CNRS ERL8252, INSERM1149 Paris, France
Type
Published Article
Journal
Immunity
Publication Date
Aug 18, 2020
Volume
53
Issue
2
Pages
335–352
Identifiers
DOI: 10.1016/j.immuni.2020.06.002
PMID: 32610077
PMCID: PMC7445430
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Bourdely et al. identify human CD88−CD1c+CD163+ DC3s as a pro-inflammatory phagocyte lineage sharing features with monocytes and conventional DCs. DC3s efficiently induce differentiation of CD103+CD8+ T cells in vitro , and their infiltration correlates with CD8+CD69+CD103+ TRM accumulation in breast tumors.

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