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The transcription factor BCL-6 controls early development of innate-like T cells

Authors
  • Gioulbasani, Marianthi1
  • Galaras, Alexandros1, 2
  • Grammenoudi, Sofia1
  • Moulos, Panagiotis1
  • Dent, Alexander L.3
  • Sigvardsson, Mikael4
  • Hatzis, Pantelis1
  • Kee, Barbara L.5
  • Verykokakis, Mihalis1
  • 1 Institute for Fundamental Biomedical Research, BSRC Alexander Fleming, Vari, Greece , Vari (Greece)
  • 2 University of Thessaly, Biopolis, Greece , Biopolis (Greece)
  • 3 Indiana University School of Medicine, Indianapolis, IN, USA , Indianapolis (United States)
  • 4 Linköping University, Linköping, Sweden , Linköping (Sweden)
  • 5 University of Chicago, Chicago, IL, USA , Chicago (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Jul 27, 2020
Volume
21
Issue
9
Pages
1058–1069
Identifiers
DOI: 10.1038/s41590-020-0737-y
Source
Springer Nature
License
Yellow

Abstract

Verykokakis and colleagues show that the transcription factor BCL-6 is highly expressed in stage 0 NKT and is absolutely required for innate T cell lineage development. BCL-6 acts to modify the chromatin landscape and is needed to promote the ST0–ST1 transition and PLZF expression.

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