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Transcription. Comment on "Mechanism of eukaryotic RNA polymerase III transcription termination".

Authors
Type
Published Article
Journal
Science
1095-9203
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Volume
345
Issue
6196
Pages
524–524
Identifiers
DOI: 10.1126/science.1253783
PMID: 25082694
Source
Medline
License
Unknown

Abstract

Nielsen et al. (Reports, 28 June 2013, p. 1577) characterized their RNA polymerase III (Pol III) preparation and concluded that it requires an RNA hairpin/duplex structure for terminating transcription. We could not corroborate their findings using bona fide Pol III from two laboratory sources. We show that Pol III efficiently terminates transcription in the absence of a hairpin/duplex in vitro and in vivo.

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