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The transcobalamin (TCN2) 776C>G polymorphism affects homocysteine concentrations among subjects with low vitamin B(12) status.

Authors
Type
Published Article
Journal
European Journal of Clinical Nutrition
0954-3007
Publisher
Nature Publishing Group
Publication Date
Volume
64
Issue
11
Pages
1338–1343
Identifiers
DOI: 10.1038/ejcn.2010.157
PMID: 20808328
Source
Medline

Abstract

These data suggest that, relative to transcobalamin with arginine at position 259 (776G), transcobalamin with proline at this position (776C) is either more efficient at vitamin B(12) transport from blood to tissues or has higher affinity for vitamin B(12). Furthermore, vitamin B(12) status influences the relationship between TCN2 776C>G genotype and tHcy concentrations. Thus, the TCN2 776C>G polymorphism may contribute to the risk of pathologies associated with a low B(12), and high tHcy phenotype.

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