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Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.

Authors
  • Sprigg, Nikola1
  • Flaherty, Katie2
  • Appleton, Jason P2
  • Salman, Rustam Al-Shahi3
  • Bereczki, Daniel4
  • Beridze, Maia5
  • Christensen, Hanne6
  • Ciccone, Alfonso7
  • Collins, Ronan8
  • Czlonkowska, Anna9
  • Dineen, Robert A10
  • Duley, Lelia11
  • Egea-Guerrero, Juan Jose12
  • England, Timothy J13
  • Krishnan, Kailash14
  • Laska, Ann Charlotte15
  • Law, Zhe Kang16
  • Ozturk, Serefnur17
  • Pocock, Stuart J18
  • Roberts, Ian19
  • And 8 more
  • 1 Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, City Hospital Campus, Nottingham, UK; Stroke, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, UK. Electronic address: [email protected]
  • 2 Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, City Hospital Campus, Nottingham, UK.
  • 3 Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • 4 Department of Neurology, Semmelweis University, Budapest, Hungary. , (Hungary)
  • 5 The First University Clinic of Tbilisi State Medical University, Tbilisi, Georgia. , (Georgia)
  • 6 Department of Neurology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark. , (Denmark)
  • 7 Neurology Unit, Azienda Socio Sanitaria Territoriale di Mantova, Mantua, Italy. , (Italy)
  • 8 Stroke Service, Adelaide and Meath Hospital, Tallaght, Ireland. , (Ireland)
  • 9 2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland. , (Poland)
  • 10 Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Queens Medical Centre Campus, Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham, UK.
  • 11 Nottingham Clinical Trials Unit, University of Nottingham, Queen's Medical Centre, Nottingham, UK.
  • 12 UGC de Medicina Intensiva, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Seville, Spain. , (Spain)
  • 13 Vascular Medicine, Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby, UK.
  • 14 Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, City Hospital Campus, Nottingham, UK; Stroke, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, UK.
  • 15 Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden. , (Sweden)
  • 16 Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, City Hospital Campus, Nottingham, UK; Stroke, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, UK; Department of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia. , (Malaysia)
  • 17 Department of Neurology, Selcuk University Medical Faculty, Konya, Turkey. , (Turkey)
  • 18 Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK.
  • 19 Clinical Trials Unit, London School of Hygiene & Tropical Medicine, London, UK.
  • 20 Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • 21 Stroke Research, Faculty of Medicine and Health Sciences, Keele University, Staffordshire, UK.
  • 22 Stroke Center, Neurology and Department of Clinical Research, University Hospital, University Basel, Basel, Switzerland. , (Switzerland)
  • 23 Division of Neurosurgery, Department of Surgery, National University of Malaysia, Kuala Lumpur, Malaysia. , (Malaysia)
  • 24 Stroke Research Centre, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, University College London, London, UK.
  • 25 School of Economics, University of Nottingham, University Park, Nottingham, UK.
Type
Published Article
Journal
The Lancet
Publisher
Elsevier
Publication Date
May 26, 2018
Volume
391
Issue
10135
Pages
2107–2115
Identifiers
DOI: 10.1016/S0140-6736(18)31033-X
PMID: 29778325
Source
Medline
License
Unknown

Abstract

National Institute of Health Research Health Technology Assessment Programme and Swiss Heart Foundation.

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