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Trajectory of cartilage loss within 4 years of knee replacement--a nested case-control study from the osteoarthritis initiative.

Authors
  • Eckstein, F1
  • Boudreau, R M2
  • Wang, Z3
  • Hannon, M J3
  • Wirth, W4
  • Cotofana, S4
  • Guermazi, A5
  • Roemer, F6
  • Nevitt, M7
  • John, M R8
  • Ladel, C9
  • Sharma, L10
  • Hunter, D J11
  • Kwoh, C K12
  • 1 Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany. Electronic address: [email protected] , (Austria)
  • 2 Department of Epidemiology, Grad. Sch. of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
  • 3 Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • 4 Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany. , (Austria)
  • 5 Department of Radiology, Boston University School of Medicine & Boston Imaging Core Lab (BICL), LLC, Boston, MA, USA.
  • 6 Department of Radiology, Boston University School of Medicine & Boston Imaging Core Lab (BICL), LLC, Boston, MA, USA; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany. , (Germany)
  • 7 OAI Coordinating Ctr., UCSF, San Francisco, CA, USA.
  • 8 Novartis Pharma AG, Basel, Switzerland. , (Switzerland)
  • 9 Merck KGaA, Darmstadt, Germany. , (Germany)
  • 10 Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • 11 Royal North Shore Hospital & Northern Clinical School, University Sydney, Sydney, Australia. , (Australia)
  • 12 Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Division of Rheumatology and University of Arizona Arthritis Center, University of Arizona College of Medicine, Tucson, AZ, USA.
Type
Published Article
Journal
Osteoarthritis and Cartilage
Publisher
Elsevier
Publication Date
October 2014
Volume
22
Issue
10
Pages
1542–1549
Identifiers
DOI: 10.1016/j.joca.2014.04.016
PMID: 24792212
Source
Medline
Keywords
License
Unknown

Abstract

In knees with subsequent replacement, cartilage loss accelerates in the 2 years, and particularly in the year prior to surgery, compared with controls. Whether slowing this cartilage loss can delay KR remains to be determined.

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