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Tracking the MEN1 gene.

Authors
Type
Published Article
Journal
The American Journal of Surgery
0002-9610
Publisher
Elsevier
Publication Date
Volume
174
Issue
3
Pages
266–270
Identifiers
PMID: 9324134
Source
Medline
License
Unknown

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is a hereditary autosomal dominant disease characterized by parathyroid hyperplasia, pancreatic endocrine tumors, and pituitary adenomas. Sporadic forms of these tumors are more common than their inherited counterparts and share common genetic abnormalities. We have been studying the molecular genetics of sporadic pancreatic endocrine tumors to identify the tumor suppressor gene responsible for MEN1 by positional cloning. This review introduces the reader to the fundamentals of these molecular genetic techniques and outlines the general strategy used to isolate this gene.

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