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Tracking Mechanisms of Viral Dissemination In Vivo.

Authors
  • Gaudin, Raphael1
  • Goetz, Jacky G2
  • 1 Institut de Recherche en Infectiologie de Montpellier (IRIM), CNRS, 34293 Montpellier, France; Université de Montpellier, 34090 Montpellier, France. Electronic address: [email protected] , (France)
  • 2 INSERM UMR_S1109, Tumor Biomechanics, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France. Electronic address: [email protected] , (France)
Type
Published Article
Journal
Trends in cell biology
Publication Date
Jan 01, 2021
Volume
31
Issue
1
Pages
17–23
Identifiers
DOI: 10.1016/j.tcb.2020.09.005
PMID: 33023793
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Dissemination and replication of viruses into hosts is a multistep process where viral particles infect, navigate, and indoctrinate various cell types. Viruses can reach tissues that are distant from their infection site by subverting subcellular mechanisms in ways that are, sometimes, disruptive. Modeling these steps, at appropriate resolution and within animal models, is cumbersome. Yet, mimicking these strategies in vitro fails to recapitulate the complexity of the cellular ecosystem. Here, we will discuss relevant in vivo platforms to dissect the cellular and molecular programs governing viral dissemination and briefly discuss organoid and ex vivo alternatives. We will focus on the zebrafish model and will describe how it provides a transparent window to unravel new cellular mechanisms of viral dissemination in vivo. Copyright © 2020 Elsevier Ltd. All rights reserved.

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