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TPMT genetic variants are associated with increased rejection with azathioprine use in heart transplantation.

Authors
  • Liang, Jackson J
  • Geske, Jennifer R
  • Boilson, Barry A
  • Frantz, Robert P
  • Edwards, Brooks S
  • Kushwaha, Sudhir S
  • Kremers, Walter K
  • Weinshilboum, Richard M
  • Pereira, Naveen L
Type
Published Article
Journal
Pharmacogenetics and Genomics
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Dec 01, 2013
Volume
23
Issue
12
Pages
658–665
Identifiers
DOI: 10.1097/FPC.0000000000000005
PMID: 24121523
Source
Medline
License
Unknown

Abstract

HTX recipients with TPMT genetic variant alleles who are treated with AZA develop acute rejection earlier, more frequently, and of greater severity. These patients, despite having lower TPMT enzymatic activity, should be monitored carefully for possible increased risk of acute rejection.

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