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A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion.

Authors
  • Hedl, Matija1
  • Abraham, Clara1
  • 1 Department of Internal Medicine, Yale University, New Haven, CT, USA.
Type
Published Article
Journal
Gut
Publisher
BMJ
Publication Date
Nov 01, 2016
Volume
65
Issue
11
Pages
1799–1811
Identifiers
DOI: 10.1136/gutjnl-2014-308922
PMID: 26215868
Source
Medline
Keywords
License
Unknown

Abstract

Taken together, the rs1042058 GG IBD-risk polymorphism in TPL2 results in a gain-of-function by increasing TPL2 expression and signalling, thereby amplifying PRR-initiated outcomes.

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