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Toxoplasma secretory proteins and their roles in cell invasion and intracellular survival

Authors
  • Lebrun, M.
  • Carruthers, V.B.
  • Cesbron-Delauw, M.-F.
Type
Book
Journal
Toxoplasma Gondii
Publication Date
Jan 01, 2007
Pages
265–316
Identifiers
DOI: 10.1016/B978-012369542-0/50013-1
ISBN: 978-0-12-369542-0
Source
Elsevier
License
Unknown

Abstract

This chapter highlights the key elements involved in invasion and emphasizes the sequential exocytosis of secretory organelles, including some peripheral aspects such as protein trafficking toorganelles and biogenesis of the parasitophorous vacuole. Toxoplasma pathogenesis is intimately associated with the parasite's ability to invade host cells—an active process that has no counterpart outside the Apicomplexa phylum. The mechanisms involved are likely to be similar throughout the phylum, as first exemplified by the conservation of a family of microneme proteins containing thrombospondin-related domains first identified in Plasmodium spp. The development of modern genetic analysis in T. gondii has facilitated improvement in knowledge regarding the invasion process of T. gondii, and has helped in identifying the key molecular actors of the invasion machinery of Plasmodium—a parasite that is less amenable to genetic manipulation.

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