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Toxoplasma gondii IgG associations with sleepwake problems, sleep duration and timing

Authors
  • Corona, Celine C.1
  • Zhang, Man2
  • Wadhawan, Abhishek1, 3
  • Daue, Melanie L.2, 4, 5
  • Groer, Maureen W.6
  • Dagdag, Aline1, 7
  • Lowry, Christopher A.8, 9
  • Hoisington, Andrew J.9, 10
  • Ryan, Kathleen A.2, 4
  • Stiller, John W.1, 11
  • Fuchs, Dietmar12
  • Mitchell, Braxton D.2, 4, 5
  • Postolache, Teodor T.13
  • 1 Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine,, USA , (United States)
  • 2 Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine,, USA , (United States)
  • 3 Saint Elizabeths Hospital, Psychiatry Residency Program,, USA , (United States)
  • 4 Program for Personalized and Genomic Medicine, University of Maryland School of Medicine,, USA , (United States)
  • 5 Geriatrics Research and Education Clinical Center, Veteran Affairs Medical Center,, USA , (United States)
  • 6 College of Nursing , University of South Florida Coleege of Nursing ,, USA , (United States)
  • 7 Psychiatry Adult Inpatient & Behavorial Health , University of Maryland Medical Center ,, USA , (United States)
  • 8 Departament of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder , Boulder ,CO 80309, USA ;Departament of Physical Medicine and Rehabilitation and Center for Neuroscience, University of Colorado Anschutz Medical Campus ,, USA , (United States)
  • 9 Rocky Mountain Mentall Illness Researcher Education and Clinical Center( MIRECC) , Veterans Integrated Service Network (VISN) 19, Military and Veteran. Microbime:Consortium for Research and Education (MVM-CoRE),, USA , (United States)
  • 10 Departament of Systems Engineering and Management , Air Force Institute of Technology ,, USA , (United States)
  • 11 Saint Elizabeths , Hospital , Departament of Neurology , Washington DC 20032 ,USA; Maryland State Athletic Commission ,, USA , (United States)
  • 12 Division of Biological Chemistry, Biocenter, Innsbruck Medical University,, Austria , (Austria)
  • 13 Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Veterans Integrated Service Network (VISN) 19, Military and Veteran. Microbiome: Consortium for Research and Education (MVM-CoRE), Aurora, CO 80045, USA; Mental Illness Research, Education and Clinical Center (MIRECC), Veterans Integrated Service Network (VISN) 5, VA Capitol Health Center Network,, USA , (United States)
Type
Published Article
Journal
Pteridines
Publisher
De Gruyter Open
Publication Date
Feb 19, 2019
Volume
30
Issue
1
Pages
1–9
Identifiers
DOI: 10.1515/pteridines-2019-0001
Source
De Gruyter
Keywords
License
Green

Abstract

Background: Evidence links Toxoplasma gondii (T. gondii), a neurotropic parasite, with schizophrenia, mood disorders and suicidal behavior, all of which are associated and exacerbated by disrupted sleep. Moreover, low-grade immune activation and dopaminergic overstimulation, which are consequences of T. gondii infection, could alter sleep patterns and duration. Methods: Sleep data on 833 Amish participants [mean age (SD) = 44.28 (16.99) years; 59.06% women] were obtained via self-reported questionnaires that assessed sleep problems, duration and timing. T. gondii IgG was measured with ELISA. Data were analyzed using multivariable logistic regressions and linear mixed models, with adjustment for age, sex and family structure. Results: T. gondii seropositives reported less sleep problems (p < 0.005) and less daytime problems due to poor sleep (p < 0.005). Higher T. gondii titers were associated with longer sleep duration (p < 0.05), earlier bedtime (p < 0.005) and earlier mid-sleep time (p < 0.05). Conclusions: It seems unlikely that sleep mediates the previously reported associations between T. gondii and mental illness. Future longitudinal studies with objective measures are necessary to replicate our findings.

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