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Toxicogenetics: in search of host susceptibility to environmental toxicants.

Authors
  • Alam, Gelareh
  • Jones, Byron C
Type
Published Article
Journal
Frontiers in Genetics
Publisher
Frontiers Media SA
Publication Date
Jan 01, 2014
Volume
5
Pages
327–327
Identifiers
DOI: 10.3389/fgene.2014.00327
PMID: 25295052
Source
Medline
Keywords
License
Unknown

Abstract

Heavy metals, various pesticide and herbicides are implicated as risk factors for human health. Paraquat, maneb, and rotenone, carbamate, and organophosphorous insecticides are examples of toxicants for which acute and chronic exposure are associated with multiple neurological disorders including Parkinson's disease. Nevertheless, the role of pesticide exposure in neurodegenerative diseases is not clear-cut, as there are inconsistencies in both the epidemiological and preclinical research. The aim of this short review is to show that at least, some of the inconsistencies are related to individual differences in susceptibility to the effects of neurotoxicants, individual differences that can be traced to the genetic constitution of the individuals and animals studies, i.e., host-based susceptibility.

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