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Toxicity potential of compounds found in parenteral solutions with rubber stoppers.

Authors
Type
Published Article
Journal
Journal of parenteral science and technology : a publication of the Parenteral Drug Association
Publication Date
Volume
46
Issue
2
Pages
43–47
Identifiers
PMID: 1588456
Source
Medline
License
Unknown

Abstract

Leached stopper components found in parenteral solutions produced by several manufacturers were identified and quantitated. Their toxicity potential was determined by comparing the types and quantities of the leached components with known toxicity levels and/or harmful effects. Toxicity potentials for benzaldehyde, 2-butoxyethanol, cyclohexanone, ethylbenzene, 1,1,2,2-tetrachloroethane, and tetrachloroethylene are listed. Breakdown products of dextrose (furfural and 5-hydroxymethylfurfural), which may also have harmful effects, were quantitated.

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