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Toxicity, biodistribution, and convection-enhanced delivery of the boronated porphyrin BOPP in the 9L intracerebral rat glioma model.

Authors
  • Ozawa, Tomoko
  • Afzal, Javed
  • Lamborn, Kathleen R
  • Bollen, Andrew W
  • Bauer, William F
  • Koo, Myoung-Seo
  • Kahl, Stephen B
  • Deen, Dennis F
Type
Published Article
Journal
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier
Publication Date
Sep 01, 2005
Volume
63
Issue
1
Pages
247–252
Identifiers
PMID: 16111595
Source
Medline
License
Unknown

Abstract

Our study demonstrates that changing the method of BOPP delivery from i.v. to CED significantly enhances the boron concentration in tumors and produces very favorable tumor/brain and tumor/blood ratios.

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