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Toxic vessel reaction to an absorbable polymer-based paclitaxel-eluting stent in pig coronary arteries.

Authors
  • Jabara, Refat
  • Chronos, Nicolas
  • Tondato, Fernando
  • Conway, Damian
  • Molema, Warner
  • Park, Kenneth
  • Mabin, Tom
  • King, Spencer
  • Robinson, Keith
Type
Published Article
Journal
The Journal of invasive cardiology
Publication Date
Aug 01, 2006
Volume
18
Issue
8
Pages
383–390
Identifiers
PMID: 16877788
Source
Medline
License
Unknown

Abstract

Despite in vitro data showing slow, sustained release of paclitaxel from a bioabsorbable polymer, the porcine coronary artery model demonstrated a sequence of medial necrosis, stent malapposition and late neointimal thickening. Since the therapeutic window for paclitaxel may be narrower than currently inferred, thorough preclinical testing coupled with the polymer development process for stents eluting paclitaxel is needed.

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