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[Toxic effects of moniliformin on heart function in rats].

Authors
Type
Published Article
Journal
Zhonghua yi xue za zhi
Publication Date
Volume
70
Issue
11
Identifiers
PMID: 1963353
Source
Medline
License
Unknown

Abstract

The present study was carried out on intact heart of rat to determine the myocardial toxicity of moniliformin (MLFN) in vitro and in vivo Perfusion of MLFN 0.1 mumol/L in isolated heart decreased myocardial contractile force by 52 +/- 17%, and the effect was not reversible after the infusion of MLFN had stopped. The intravenous LD50 of MLFN in mice was found to be 17.51 +/- 1.64 mg/kg. Intravenous injection of MLFN at 1/4 LD50 markedly inhibited cardiac hemodynamic variables relative to myocardial contractile function. Particularly, it decreased left ventricular pressure development (dP/dt max) by 52 +/- 6%, and induced ventricular arrhythmia. The results showed that MLFN severely damaged the heart function of healthy rats.

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