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Towards the endgame and beyond: complexities and challenges for the elimination of infectious diseases.

Authors
  • Klepac, Petra1
  • Metcalf, C Jessica E
  • McLean, Angela R
  • Hampson, Katie
  • 1 Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, UK.
Type
Published Article
Journal
Philosophical Transactions of The Royal Society B Biological Sciences
Publisher
The Royal Society
Publication Date
Aug 05, 2013
Volume
368
Issue
1623
Pages
20120137–20120137
Identifiers
DOI: 10.1098/rstb.2012.0137
PMID: 23798686
Source
Medline
Keywords
License
Unknown

Abstract

Successful control measures have interrupted the local transmission of human infectious diseases such as measles, malaria and polio, and saved and improved billions of lives. Similarly, control efforts have massively reduced the incidence of many infectious diseases of animals, such as rabies and rinderpest, with positive benefits for human health and livelihoods across the globe. However, disease elimination has proven an elusive goal, with only one human and one animal pathogen globally eradicated. As elimination targets expand to regional and even global levels, hurdles may emerge within the endgame when infections are circulating at very low levels, turning the last mile of these public health marathons into the longest mile. In this theme issue, we bring together recurring challenges that emerge as we move towards elimination, highlighting the unanticipated consequences of particular ecologies and pathologies of infection, and approaches to their management.

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