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Towards the development of anticancer drugs from Andrographolide: Semisynthesis, Bioevaluation, QSAR analysis and Pharmacokinetic studies

Authors
Type
Published Article
Journal
Current Topics in Medicinal Chemistry
Publisher
Bentham Science
Volume
15

Abstract

Isolation of andrographolide from Andrographis paniculata, preparation of a library derivatives via 1,3-dipolar cycloaddition of andrographolide with azomethine ylides generated from isatin derivatives or acenaphthoquinone and seconday α-amino acids, evaluation of the anticancer potential of the products, quantitative structure activity relationship studies and pharmacokinetic parameter determination have been described. see more at:http://benthamscience.com/journal/abstracts.php?journalID=ctmc&articleID=129592

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