Affordable Access

Towards stem-cell therapy in the endocrine pancreas.

Authors
  • Gangaram-Panday, Shanti T
  • Faas, Marijke M
  • de Vos, Paul
Type
Published Article
Journal
Trends in Molecular Medicine
Publisher
Elsevier
Publication Date
Apr 01, 2007
Volume
13
Issue
4
Pages
164–173
Identifiers
PMID: 17307397
Source
Medline
License
Unknown

Abstract

Many approaches of stem-cell therapy for the treatment of diabetes have been described. One is the application of stem cells for replacement of nonfunctional islet cells in the native endogenous pancreas; another one is the use of stem cells as an inexhaustible source for islet-cell transplantation. During recent years three types of stem cells have been investigated: embryonic stem cells, bone-marrow-derived stem cells and organ-bound stem cells. We discuss the advantages and limitations of these different cell types. The applicability for the treatment of dysfunction of beta cells in the pancreas has been demonstrated for all three cell types, but more-detailed understanding of the sequence of events during differentiation is required to produce fully functional insulin-producing cells.

Report this publication

Statistics

Seen <100 times