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[Towards a standardization of the tools for the studies of clinical proteomics].

Authors
  • Lucchi, Géraldine
  • Hendra, Jean-Baptiste
  • Pecqueur, Delphine
  • Ducoroy, Patrick
Type
Published Article
Journal
Médecine sciences : M/S
Publication Date
Mar 01, 2007
Volume
23 Spec No 1
Pages
19–22
Identifiers
PMID: 17669348
Source
Medline
License
Unknown

Abstract

Proteins identified in biological fluids of cancer patients could be helpful for both diagnosis and prognosis. However, clinical proteomics based on analysis of protein profiles in biological fluids has demonstrated various flaws, most of them related to the difficulties met in reproducibility. These difficulties could be partly overcome by accurate standardisation of pre-analytical and analytical steps of these studies. The size of the patient cohort is one of the parameters that determine the powerfulness of the study. Recruitment of a cohort with a sufficient size often implies multicentric studies in which analysis of the reproducibility between centres and standardisation of pre-analytical and analytical steps are essential. Such a standardisation requires the use of calibrated samples as common references.

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