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Towards retinoid therapy for Alzheimer's disease.

Authors
  • Shudo, K
  • Fukasawa, H
  • Nakagomi, M
  • Yamagata, N
Type
Published Article
Journal
Current Alzheimer Research
Publisher
Bentham Science
Publication Date
Jun 01, 2009
Volume
6
Issue
3
Pages
302–311
Identifiers
PMID: 19519313
Source
Medline
License
Unknown

Abstract

Alzheimer's disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and age-related changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD.

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