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Towards precision public health: Geospatial analytics and sensitivity/specificity assessments to inform liver cancer prevention.

Authors
  • Lynch, Shannon M1
  • Wiese, Daniel2
  • Ortiz, Angel1
  • Sorice, Kristen A1
  • Nguyen, Minhhuyen1
  • González, Evelyn T1
  • Henry, Kevin A1, 2
  • 1 Cancer Prevention and Control, Fox Chase Cancer Center, Philadelphia, PA, USA.
  • 2 Geography and Urban Studies, Temple University, Philadelphia, PA, USA.
Type
Published Article
Journal
SSM - population health
Publication Date
Dec 01, 2020
Volume
12
Pages
100640–100640
Identifiers
DOI: 10.1016/j.ssmph.2020.100640
PMID: 32885020
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Liver cancer (LC) continues to rise, partially due to limited resources for prevention. To test the precision public health (PPH) hypothesis that fewer areas in need of LC prevention could be identified by combining existing surveillance data, we compared the sensitivity/specificity of standard recommendations to target geographic areas using U.S. Census demographic data only (percent (%) Hispanic, Black, and those born 1950-1959) to an alternative approach that couples additional geospatial data, including neighborhood socioeconomic status (nSES), with LC disease statistics. Pennsylvania Cancer Registry data from 2007-2014 were linked to 2010 U.S. Census data at the Census tract (CT) level. CTs in the top 80th percentile for 3 standard demographic variables, %Hispanic, %Black, %born 1950-1959, were identified. Spatial scan statistics (SatScan) identified CTs with significantly elevated incident LC rates (p-value<0.05), adjusting for age, gender, diagnosis year. Sensitivity, specificity, and positive predictive value (PPV) of a CT being located in an elevated risk cluster and/or testing positive/negative for at least one standard variable were calculated. nSES variables (deprivation, stability, segregation) significantly associated with LC in regression models (p < 0.05) were systematically evaluated for improvements in sensitivity/specificity. 9,460 LC cases were diagnosed across 3,217 CTs. 1,596 CTs were positive for at least one of 3 standard variables. 5 significant elevated risk clusters (CTs = 402) were identified. 324 CTs were positive for a high risk cluster AND standard variable (sensitivity = 92%; specificity = 37%; PPV = 17.4%). Incorporation of 3 new nSES variables with one standard variable (%Black) further improved sensitivity (93%), specificity (62.9%), and PPV (26.3%). We introduce a quantitative assessment of PPH by applying established sensitivity/specificity assessments to geospatial data. Coupling existing disease cluster and nSES data can more precisely identify intervention targets with a liver cancer burden than standard demographic variables. Thus, this approach may inform prioritization of limited resources for liver cancer prevention. © 2020 The Authors.

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