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Ultra-Marathon-Induced Increase in Serum Levels of Vitamin D Metabolites: A Double-Blind Randomized Controlled Trial.

Authors
  • Mieszkowski, Jan1
  • Stankiewicz, Błażej2
  • Kochanowicz, Andrzej1
  • Niespodziński, Bartłomiej2
  • Kowalik, Tomasz2
  • Żmijewski, Michał3
  • Kowalski, Konrad4
  • Rola, Rafał4, 5
  • Bieńkowski, Tomasz4
  • Antosiewicz, Jędrzej6
  • 1 Department of Gymnastics and Dance, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland. , (Poland)
  • 2 Institute of Physical Education, Kazimierz Wielki University, 85-064 Bydgoszcz, Poland. , (Poland)
  • 3 Department of Histology, Medical University of Gdańsk, 80-211 Gdansk, Poland. , (Poland)
  • 4 Masdiag Sp. z o.o. Company, 01-882 Warsaw, Poland. , (Poland)
  • 5 Chair of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland. , (Poland)
  • 6 Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, 80-210 Gdansk, Poland. , (Poland)
Type
Published Article
Journal
Nutrients
Publisher
MDPI AG
Publication Date
Nov 25, 2020
Volume
12
Issue
12
Identifiers
DOI: 10.3390/nu12123629
PMID: 33255807
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

While an increasing number of studies demonstrate the importance of vitamin D for athletic performance, the effects of any type of exercise on vitamin D metabolism are poorly characterized. We aimed to identify the responses of some vitamin D metabolites to ultra-marathon runs. A repeated-measures design was implemented, in which 27 amateur runners were assigned into two groups: those who received a single dose of vitamin D3 (150,000 IU) 24 h before the start of the marathon (n = 13) and those (n = 14) who received a placebo. Blood samples were collected 24 h before, immediately after, and 24 h after the run. In both groups of runners, serum 25(OH)D3, 24,25(OH)2D3, and 3-epi-25(OH)D3 levels significantly increased by 83%, 63%, and 182% after the ultra-marathon, respectively. The increase was most pronounced in the vitamin D group. Body mass and fat mass significantly decreased after the run in both groups. Ultra-marathon induces the mobilization of vitamin D into the blood. Furthermore, the 24,25(OH)2D3 and 3-epi-25(OH)D3 increases imply that the exercise stimulates vitamin D metabolism.

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