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Towards computational models of cells for environmental toxicology.

Authors
  • Allen, J Icarus
  • McVeigh, Allan
Type
Published Article
Journal
Journal of molecular histology
Publication Date
Sep 01, 2004
Volume
35
Issue
7
Pages
697–706
Identifiers
PMID: 15614625
Source
Medline
License
Unknown

Abstract

This paper outlines an approach to the development of computational models of cells for marine environmental toxicology. Exposure of cells to pollutants can lead to lysosomal damage and dysfunction, augmented autophagy, cellular dysfunction and atrophy and ultimately tissue pathology and organ damage. The application of carbon and nitrogen based models of intra cellular vesicular traffic for simulating the autophagic and lysosomal response of the hepatopancreatic digestive cells of marine molluscs is described. Two numerical models of the vesicular transport of carbon and nitrogen in the cell are presented. These demonstrate the importance of endocytotic uptake as a driver of lysosomal dynamics and the need to recognize and model it as a discrete process. Conceptual and mathematical models of the toxic impact of polycyclic aromatic hydrocarbons on the digestive gland are presented. The role of experimental research and the need to integrate it with modelling is highlighted.

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