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Tourette syndrome or PANDAS-a case report.

Authors
  • Singh, Rhea1
  • Nekrasova, Nataliya2
  • Butov, Dmytro3
  • 1 Kharkiv National Medical University, Kharkiv, Ukraine. , (Ukraine)
  • 2 Neurology department №2, Kharkiv National Medical University, Kharkiv, Ukraine. , (Ukraine)
  • 3 Kharkiv National Medical University, Kharkiv, Ukraine. [email protected] , (Ukraine)
Type
Published Article
Journal
Wiener medizinische Wochenschrift (1946)
Publication Date
Sep 01, 2021
Volume
171
Issue
11-12
Pages
289–292
Identifiers
DOI: 10.1007/s10354-020-00779-6
PMID: 32955635
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Tourette syndrome (TS), a relatively common disorder, has been gaining more attention during the past two decades because of an increased number of reports. Nevertheless, it is still not completely understood. Furthermore, a clinical entity called "pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections" (PANDAS) has been introduced, which describes a tic disorder, accompanied by psychiatric disorders such as obsessive compulsive disorder (OCD), after a streptococcal infection in childhood. We present a case report of a 19-year-old adolescent Ukrainian female, with a history of anxiety disorder and OCD, who, despite TS remission during childhood, presented with new-onset motor and phonic tics after 1 month of severe tonsillitis. Blood and cerebrospinal cultures showed Streptococcus pyogenes, with magnetic resonance imaging revealing hypo-intense changes in the caudate nucleus on both sides. Treatment with clonazepam and fluoxetine, along with behavioral therapy, have improved the severity of her condition. This report presents a case of TS reemergence against the background of immunological reaction or PANDAS with a late adolescent onset. © 2020. Springer-Verlag GmbH Austria, ein Teil von Springer Nature.

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