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Total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' found in Madagascan frogs (Mantella) and their affinities for nicotinic acetylcholine receptor.

Authors
  • Takahata, H
  • Takahashi, S
  • Azer, N
  • Eldefrawi, A T
  • Eldefrawi, M E
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jun 05, 2000
Volume
10
Issue
11
Pages
1293–1295
Identifiers
PMID: 10866403
Source
Medline
License
Unknown

Abstract

The total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' has been achieved starting from 1,5-hexadiene via a common synthetic intermediate 5. The affinity of 1-4 for nicotinic acetylcholine receptor was evaluated.

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