The total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' has been achieved starting from 1,5-hexadiene via a common synthetic intermediate 5. The affinity of 1-4 for nicotinic acetylcholine receptor was evaluated.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/10866403