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Total synthesis of the proposed structure of cyclic hexadepsipeptide veraguamide A.

Authors
Type
Published Article
Journal
Organic & Biomolecular Chemistry
1477-0539
Publisher
The Royal Society of Chemistry
Publication Date
Volume
10
Issue
35
Pages
7027–7030
Identifiers
DOI: 10.1039/c2ob26002f
PMID: 22858902
Source
Medline

Abstract

We have developed a practical method to assemble the proposed structure of natural product veraguamide A (1) by first preparing the three key fragments followed by optimization of the macrocyclization site. Although the synthetic product gave similar optical rotation to that reported for natural product, significant differences in the (1)H and (13)C NMR spectra were observed, especially the proton and carbon signals in the two N-MeVal moieties.

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