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The TORC1-regulated CPA complex rewires an RNA processing network to drive autophagy and metabolic reprogramming

Authors
  • Tang, Hong-Wen1
  • Hu, Yanhui1
  • Chen, Chiao-Lin1
  • Xia, Baolong1
  • Zirin, Jonathan1
  • Yuan, Min2, 3
  • Asara, John M.2, 3
  • Rabinow, Leonard1
  • Perrimon, Norbert1, 4
  • 1 Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
  • 2 Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
  • 3 Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
  • 4 Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Type
Published Article
Journal
Cell metabolism
Publication Date
Mar 29, 2018
Volume
27
Issue
5
Pages
1040–1054
Identifiers
DOI: 10.1016/j.cmet.2018.02.023
PMID: 29606597
PMCID: PMC6100782
Source
PubMed Central
Keywords
License
Unknown

Abstract

Tang et al. investigate the mechanisms of how TORC1 regulates autophagy and cell metabolism. They demonstrate that CDK8 and DOA, two kinases downstream of TORC1 signaling, directly phosphorylate CPSF6 to regulate alternative RNA polyadenylation and splicing and mediate TORC1-dependnt physiological functions.

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