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The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C.

Authors
  • Ho, Anita K1
  • Wagstaff, Jane L2
  • Manna, Paul T1
  • Wartosch, Lena1
  • Qamar, Seema1
  • Garman, Elspeth F3
  • Freund, Stefan M V2
  • Roberts, Rhys C4
  • 1 Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.
  • 2 MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.
  • 3 Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
  • 4 Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK. [email protected]
Type
Published Article
Journal
BMC Biology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Dec 07, 2016
Volume
14
Issue
1
Pages
109–109
Identifiers
PMID: 27927196
Source
Medline
Keywords
License
Unknown

Abstract

In addition to the structural characterisation of LITAF, these data lead us to propose that an aberrant LITAF-PE interaction on the surface of intracellular membranes contributes to the molecular pathogenesis that underlies this currently incurable disease.

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